Snake venom–producing organoids

Immunotherapeutic organoids

Therapeutic monoclonal antibodies have revolutionized the treatment of cancer and other diseases. However, several limitations of antibody-based treatments, such as the cost of therapy and the achievement of sustained plasma levels, should be still addressed for their widespread use as therapeutics. The use of cell and gene transfer methods offers additional benefits by producing a continuous r...

Organoids: a Special Issue.

I am delighted to introduce this Special Issue of Development, focussing on the emerging field of organoid biology. An organoid can be defined as an artificially grown mass of cells or tissue that resembles an organ. This term has grown in use within the research field over the past few years as a result of advances in two distinct directions: the isolation and propagation of adult stem cell ni...

Establishment of Gastrointestinal Epithelial Organoids.

The intestinal epithelium constitutes a system of constant and rapid renewal triggered by proliferation of intestinal stem cells (ISCs), and is an ideal system for studying cell proliferation, migration, and differentiation. Primary cell cultures have proven to be promising for unraveling the mechanisms involved in epithelium homeostasis. In 2009, Sato et al. established a long-term primary cul...

Snake Venom, Anti-snake Venom & Potential of Snake Venom

Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer. Snake venom toxins contributed significantly to the treatment of many medical conditions. Venomous snakes have a bad reputation and rightly so because of their often deadly bites. But what makes a snake’s bite so deadly is the venom. Of the 3000 snake ...

Kidney organoids for disease modeling